Purification and properties of a haemolysin produced by group A haemolytic streptococci (streptolysin O)
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چکیده
منابع مشابه
Purification and properties of an extracellular blastogen produced by group A streptococci
An extracellular product of group A streptococci which induces lymphocyte blastogenesis has been purified to homogeneity by DEAE-cellulose and CM-cellulose chromatography. The protein, termed streptococcal blastogen A, has a mol wt of approximately or equal to 17,500 and is inactivated by protease treatment and by heating at 100 degrees C. The purified blastogen gave rise to multiple protein ba...
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Although the toxicity of streptolysin O (SLO) and streptolysin S (SLS) in purified group A streptococci (GAS) has been established, the effect of these molecules in natural infection is not well understood. To identify whether biologically relevant concentrations of SLO and SLS were cytotoxic to epithelial and phagocytic cells that the bacteria would typically encounter during human infection a...
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15 صفحه اولThe Purification and Properties of Streptolysin S
Considerable purification of streptolysin S has been achieved by fractionation of crude bacterial filtrates with methanol, under controlled conditions of pH, ionic strength, and temperature. The final material (P III) consisted of two electrophoretic components. The purified material was employed for kinetic studies, the results of which were confirmed with hemolysin isolated electrophoreticall...
متن کاملStreptolysin S and necrotising infections produced by group G streptococcus.
BACKGROUND We encountered three patients with severe necrotising soft tissue infections due to beta-haemolytic group G streptococcus. Due to strong clinical similarities with invasive infections produced by group A streptococcus, we investigated a potential link of shared beta-haemolytic phenotype to disease pathogenesis. METHODS Hybridisation, DNA sequencing, targeted mutagenesis, and comple...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1941
ISSN: 0306-3283
DOI: 10.1042/bj0351124